A skull hand tattoo typically symbolizes death and mortality. It is a way of reminding the wearer that life is finite, and that they should take the time in their life to enjoy the things they are passionate about. The skull has long been associated with a reminder of death and of the fragility of life. The hand may represent luck or strength, which would indicate that even when life throws challenges at us, we can still meet them with strength and courage. Ultimately, this tattoo speaks to accepting responsibility for oneself, living life with purpose and passion, and facing mortality with an awareness of its power.