A skeleton hand tattoo typically symbolizes death and mortality, representing a reminder to live life to the fullest. It can also represent a respect for the dead, or a way to honor someone who has passed on. Additionally, it can be seen as a celebration of life, both living and gone, as the bones still remain in some form. For some, the skeleton hand tattoo is a reminder to be thankful for the life they have and to use it to the fullest. It can symbolize strength and courage in the face of death, and a refusal to be afraid.